Nanoparticles in biomedical imaging 1
Published on: Mar 3, 2016
Transcripts - Nanoparticles in biomedical imaging 1
Nanoparticles inBiomedical ImagingBy: Patrick Keyser, Charlie West, Zoë Sawyer
Hydrodynamic diameter (HD) ranges for nano-scale materials useful forbiomedical imaging (top row) and naturally-occurring materials (bottom row).http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3017480/figure/F1/Because of their large size compared to small molecules, and theirmulti-functionality, nanoparticles (NPs) hold promise as biomedicalimaging, diagnostic, and theragnostic agents. However, the key to theirsuccess hinges on a detailed understanding of their behavior afteradministration into the body.
Because of theirstrong magneticproperties, the SPIOnanoparticles canhelp overcome thepoor sensitivity ofcurrent contrastagents bygenerating highercontrast betweenthe target and thebackground. ThusSPIO nanoparticlesare a great contrastagent.http://legacy.jyi.org/features/ft.php?id=750
Magnetic iron oxide nanoparticles have been used extensively in MRI’sbecause of their ability to shorten the T2 relaxation times in liver,spleen, and bone marrow. This allows the hydrogen protons to movecloser to the magnet, which is connected to an advanced super computerto create a better image.http://med.brown.edu/pedisurg/Brown/IBImages/Spleen/SplLymph2.html
Up Next are a Few Different Kind ofNanoparticles Used Today inImaging
Purpose: diagnostic immunoassay, gene transfection,biomolecule separation, cell separation, enzymeimmobilization, drug delivery, Biomedical imagingThe surface of the supperparamagnetic Fe3O4nanoparticles is covalently functionalized with rich primaryaliphatic amine groups, and can be used for furtherfunctionalization.Amine FunctionalizedMagnetic Nanoparticleshttp://www.gignano.com/products/magnetic-nanoparticles/functionalized-magnetic-nanoparticles/amino-group-functionalized-magnetic-nanoparticles/
Carboxyl Functionalized MagneticNanoparticlesThe surface of the supperparamagnetic Fe3O4 nanoparticle is covalentlyfunctionalized with rich carboxyl groups, and can be used for furtherfunctionalization.Purpose: diagnostic immunoassay, gene transfection, biomoleculeseparation, cell separation, enzyme immobilization, drug delivery,Biomedical imaginghttp://www.gignano.com/products/magnetic-nanoparticles/functionalized-magnetic-nanoparticles/amino-group-functionalized-magnetic-nanoparticles/
Epoxy Functionalized MagneticNanoparticlesThe surface of the supperparamagnetic Fe3O4 nanoparticle is covalentlyfunctionalized with rich epoxy groups, and can be used for furtherfunctionalization.Purpose: diagnostic immunoassay, gene transfection, biomolecule separation,cell separation, enzyme immobilization, drug delivery, Biomedical imaging
IDA Functionalized MagneticNanoparticlesThe surface of the supperparamagnetic Fe3O4 nanoparticle iscovalently functionalized with rich IDA groups, and can be chelated tometal ions.Purpose: biomolecule separation, cell separation, enzymeimmobilization, heavy metal wastewater treatment, drug delivery,Biomedical imaginghttp://www.gignano.com/products/magnetic-nanoparticles/functionalized-magnetic-nanoparticles/amino-group-functionalized-magnetic-nanoparticles/
Magnet Nanoparticles• Today many nanoparticles that exibit metalicproperties are used in MRI and different types ofimaging.• Other types of nanoparticles today are used toconduct selective enrichment of different moleculesin our body that researchers need to advance ourtechnology.• The big target today for nanoparticles is drugdelivery, and using nanoparticles to help cancerresearch. Water-insoluble anticancer drugs weredelivered into human cancer cells; surfaceconjugation with cancer-specific targeting agentsincreased the uptake into cancer cells relative to thatin non-cancerous fibroblasts. The highly versatilemultifunctional nanoparticles could potentially beused for simultaneous imaging and therapeuticapplications.http://pubs.acs.org/doi/abs/10.1021/nn800072t
Because of the low abundance ofphosphopeptides/glycopeptides,specific and sensitive strategies areespecially indispensable for theidentification of proteinphosphorylation and glycosylation bymass spectrometry (MS). However,most of those previously reportedmethods only focused on enrichingeither phosphopeptides orglycopeptides rather than enrichingboth of them. In the present study,amine-functionalized magneticnanoparticles were synthesized in aone-pot procedure and successfullyused for selective enrichment of bothphosphopeptides and glycopeptides.Use of all these nanoparticleshttp://www.gignano.com/products/magnetic-nanoparticles/functionalized-magnetic-nanoparticles/amino-group-functionalized-magnetic-nanoparticles/
Works Cited"Magnetic Nanoparticles." GiGNanoBiointerface. N.p., n.d. Web. 22 Apr. 2013."The Journal of Young Investigators: AnUndergraduate, Peer-Reviewed ScienceJournal." JYI.org. N.p., n.d. Web. 22 Apr. 2013."Multifunctional Inorganic Nanoparticles forImaging, Targeting, and Drug Delivery." - ACSNano (ACS Publications). N.p., n.d. Web. 22Apr. 2013.
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