Nanoparticles for drug delivery by shreya
Published on: Mar 3, 2016
Transcripts - Nanoparticles for drug delivery by shreya
Advancement of Nanotechnology andNanoparticles in Diagnosis and DrugDelivery System for Cancer Treatment Presented By: Shreya M. Modi Centre For NanoScience, Central University of Gujarat.
CHALLENGESFormulation stability and shelf lifePrevention of drug from biological degradationEffective targetingPatient complianceCost effectivenessProduct life extension
PROPERTIES OF NANOMATERIAL
NANODEVICES FOR DRUG DELIVERYNanotubesIt helps to exactly pin point location ofthe changes at mutated regionsassociated with cancerQuantum dotsThese are tiny crystals that glow whenthese are stimulated by ultravioletlight.The latex beads filled with these crystalswhen stimulated by light,emiit the colorthat lights up the sequence of interest
CantileversTiny bars anchored at one end can beengineered to bind to moleculesassociated with cancerIt would be possible to tell whether thecancer molecules are present andhence detect early events in thedevelopment of cancer cells.NanorobotsNanorobots could be used to tag thecancerous cells, so that the surgeoncould efficiently and precisely removethe tumor.
LiposomesLiposomes are self-assembling sphericalclosed colloidal structures composed oflipid bilayers that surround a centralaqueous space.Nanoshells(NS)Absorption of light by nanoshells createsan intense heat that is lethal to cells.DendrimerDendrimers have a tree-like structurewith many branches where a variety ofmolecules, including drugs can beattached.
MicellesThey have a nano size, easymanipulation of surface chemistry,core functionalities, as well as ease offabrication, making them suitable ascarriers for encapsulation anddelivery of water insoluble agents.. Nanowire Nanowires can be coated with a probe such as an antibody that binds to a target protein. Proteins that bind to the antibody will change the nanowire’s electrical conductance and this can be measured by a detector.
ADVANTAGES Smaller Size Higher surface area Higher bioavailability Low dose required Uniform delivery of drug Can be administered via different routes Ability to incorporate hydrophilic and hydrophobic drug molecules
Conti….. Longer shelf-stability High Carrier Capacity Targeted delivery of drugs at cellular and nuclear level Longer clearance time Ability to sustain the release of drugDISADVANTAGEIt is very hard to determine dosage
ACKWLODGEMENTI am very thankful to-Prof. Man Singh Sir (Dean, CUG)Prof. M.H. Fulekar Sir (Dean, CUG)Dr. Prakash C. Jha Sir (CUG),GSBTMGSRIAnd All My Friends for their kind support