Natural Remedies For Fatigue
A guide to natural remedies for fatigue including scientific studies.
Published on: Mar 3, 2016
Transcripts - Natural Remedies For Fatigue
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"Withania somnifera, commonly known as ashwagandha, is a herb used in Ayurveda
medicine. Ashwagandha means ‘Smell of Horse, ’ which refers to the fresh root’s distinct
horsey smell, and the traditional belief that ingesting the herb will confer the strength and
virility of a horse.
"Ashwagandha is an Adaptogen. It is supplemented primarily for its ability to prevent
anxiety. Ashwagandha’s anti—anxiety effect is even synergistic with alcohol. It also shows
promise for relieving insomnia and stress—induced depression. Ashwagandha can
signiﬁcantly reduce cortisol concentrations and the immunosuppressive effect of stress. "
examine. com/ supplements/ ashwagandha/
Image credit: Wowbobwow12, commons. wikimedia. org
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Effect of standardized aqueous extract of Withania somnifera on tests of cognitive and psychomotor
performance in healthy human participants
Signiﬁcant improvements were observed in reaction times with simple reaction, choice discrimination, digit
symbol substitution, digit vigilance, and card sorting tests with Withania somnifera extract compared to placebo.
However, no effect can be seen with the ﬁnger tapping test.
These results suggest that Withania somnifera extract can improve cognitive and psychomotor performance and
may, therefore, be a valuable adjunct in the treatment of diseases associated with cognitive impairment.
ncbi. nlm. nih. gov/ pubmed/24497737
Rho liola Rosea
"Rhodiola rosea is a Traditional Chinese Medicine and Scandinavian herb touted to promote
physical/ cognitive vitality. It appears to be proven for reducing fatigue and exhaustion in
prolonged stressful situations. Rhodiola is also neuroprotective and promotes longevity in
''In regards to fatigue, rhodiola appears to be able to significantly reduce the effects of
prolonged and minor physical exhaustion that results in fatigue. This is more related to stress
and the 'burnout' effect, or prolonged but low intensity physical exercise. "
examine. com/ supplements/ rhodiola-rosea/
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Therapeutic effects and safety of Rhodiola rosea extract WS® 1375 in subjects with life-stress symptoms: results
of an open-label study
The trial was conducted to investigate the therapeutic effects and safety of a 4 week treatment with Rhodiola
rosea extract WS®1375 in subjects with | ife—stress symptoms. This was a multicentre, non—randomized,
open-label, single-arm trial. One hundred and one subjects were enrolled in this clinical study and received the
study drug at a dose of 200 mg twice daily for 4 weeks. Assessments with seven questionnaires included
Numerical Analogue Scales of Subjective Stress Symptoms, Perceived Stress Questionnaire, Multidimensional
Fatigue Inventory 20, Numbers Connecting Test, Sheehan Disability Scale and Clinical Global Impressions to cover
various aspects of stress symptoms and adverse events. lnvariably, all tests showed clinically relevant
improvements with regard to stress symptoms, disability, functional impairment and overall therapeutic effect.
Improvements were observed even after 3 days of treatment, as were continuing improvements after 1 and 4
Rhodiola rosea extract WS®1375 was safe and generally well tolerated. Adverse events were mostly of mild
intensity and no serious adverse events were reported. Rhodiola extract at a dose of 200 mg twice daily for 4
weeks is safe and effective in improving life—stress symptoms to a clinically relevant degree.
ncbi. nlm. nih. gov/ pubmed/22228617
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A randomized trial of two different doses of a SH R-5 Rhodiola rosea extract versus placebo and control of
capacity for mental work
A randomized, double—blind, placebo—controlled, para| |e| —group clinical study with an extra non—treatment group
was performed to measure the effect of a single dose of standardized SHR-5 Rhodiola rosea extract on capacity
for mental work against a background of fatigue and stress. An additional objective was to investigate a possible
difference between two doses, one dose being chosen as the standard mean dose in accordance with
wel| —estab| ished medicinal use as a psychostimulant/ adaptogen, the other dose being 50% higher. Some
physiological parameters, e. g. pulse rate, systolic and diastolic blood pressure, were also measured. The study was
carried out on a highly uniform population comprising 161 cadets aged from 19 to 21 years. All groups were found
to have very similar initial data, with no signiﬁcant difference with regard to any parameter.
The study showed a pronounced antifatigue effect reflected in an antifatigue index deﬁned as a ratio called AFI.
The verum groups had AFI mean values of1.0385 and 1.0195, 2 and 3 capsules respectively, whilst the ﬁgure for
the placebo group was 0.9046. This was statistically highly signiﬁcant (p < 0.001) for both doses (verum groups),
whilst no signiﬁcant difference between the two dosage groups was observed. There was a possible trend in favour
of the lower dose in the psychometric tests. No such trend was found in the physiological tests.
ncbi. nlm. nih. gov/ pubmed/12725561
"Heme is an iron—containing compound found in a number of biologically important
molecules. Hemoglobin and myoglobin are heme—containing proteins that are involved in the
transport and storage of oxygen.
"Cytochromes are heme-containing compounds that have important roles in mitochondrial
electron transport; therefore, cytochromes are critical to cellular energy production and
thus life. They serve as electron carriers during the synthesis of ATP, the primary energy
storage compound in cells. ”
lpi. oregonstate. edu/ mic/ minerals/ iron
Image credit: FotoosVanRobin, commons. wikimedia. org
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Iron supplementation for unexplained fatigue in non-anaemic women: double blind randomised placebo
136 (94%) women completed the study. Most had a low serum ferritin concentration; 5 20 pg/ I in 69 (51%)
women. Mean age, haemoglobin concentration, serum ferritin concentration, level of fatigue, depression, and
anxiety were similar in both groups at baseline. Both groups were also similar for compliance and dropout rates.
The level of fatigue after one month decreased by -1.82/6.37 points (29%) in the iron group compared with -
0.85/6.46 points (13%) in the placebo group (difference 0.95 points, 95% conﬁdence interval 0.32 to 1.62;
P=0.004). Subgroups analysis showed that only women with ferritin concentrations 5 50 pg/ I improved with oral
Non—anaemic women with unexplained fatigue may beneﬁt from iron supplementation. The effect may be
restricted to women with low or borderline serum ferritin concentrations.
bmj. com/ content/326/7399/1124
"Magnesium is an essential mineral and a cofactor for hundreds of enzymes. Magnesium is
involved in many physiologic pathways, including energy production.
"The metabolism of carbohydrates and fats to produce energy requires numerous
magnesium-dependent chemical reactions. Magnesium is required by the adenosine
triphosphate (ATP)—synthesizing protein in mitochondria. ATP, the molecule that provides
energy for almost all metabolic processes, exists primarily as a complex with magnesium. "
lpi. oregonstate. edu/ mic/ minerals/ magnesium
Image credit: healthaIiciousness. com
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Red blood cell magnesium and chronic fatigue syndrome
The hypotheses that patients with chronic fatigue syndrome (CFS) have low red blood cell magnesium and that
magnesium treatment would improve the wellbeing of such patients. were tested in a case—control study and a
randomised, double—blind, placebo-controlled trial, respectively. In the case—control study, 20 patients with CFS
had lower red cell magnesium concentrations than did 20 healthy control subjects matched for age, sex, and social
class (difference O-1 mmol/ I, 95% conﬁdence interval [CI] 0-05 to 0-15). In the clinical trial, 32 patients with CFS
were randomly allocated either to intramuscular magnesium sulphate every week for 6 weeks (15 patients) or to
placebo (17). Patients treated with magnesium claimed to have improved energy levels, better emotional state,
and less pain, as judged by changes in the Nottingham health proﬁle. 12 of the 15 treated patients said that they
had beneﬁted from treatment, and in 7 patients energy score improved from the maximum to the minimum. By
contrast, 3 of the 17 patients on placebo said that they felt better (difference 62%, 95% Cl 35 to 90), and 1 patient
had a better energy score. Red cell magnesium returned to normal in all patients on magnesium but in onlyl
patient on placebo. The ﬁndings show that magnesium may have a role in CFS.
sciencedirect. com/ science/ article/ pii/0140673691913712
Please note that we do not offer alternative treatment options to replace
prescription medication. This is for information only. If you have a diagnosed
health conditions and are on medication, please consult your GP ﬁrst before
trying any herbal medicines, or talk to our qualiﬁed nutritionists.