Nano Based polymers and applications in Drugs Delivery
Published on: Mar 3, 2016
Transcripts - Nano Based polymers and applications in Drugs Delivery
NANO BASED POLYMERS ANDAPPLICATIONS(DRUG DELIVERY) Presented By: Mr. Anil Kumar M.Phil./ Ph.D. Nano-science (2012-13) Centre for Nano-science Central University of Gujarat
NANO POLYMERS FORMATION Macro Micro Nano Å Å Molecules Monomers Small Bulk Material units or Micro Polymers Nano Bulk Material Polymers
Techniques Applied formation To Nano Polymers Top Down Approaches Nano Bottom Up Approaches Lysis of Bulky Materials:- Synthesis of Materials (Nano1. Chemolysis. (Use organic 1. Self Assembling. (Inter or Composites):- solvents ) Intra Molecular Nano polymers2. Thermolysis. (ΔG = ΔH – Interaction) TΔS) 2. Crystallization. ( Solid3. Radiation. (Break chemical and Liquid ) bonds, phenolic , 3. Precipitation. ( Liquid and polystyrene) Liquid recovery of salt4. Diffusion. (stirrer with high and metals) speed) 4. Sol-Gel. (NM + Organic5. Enzymolysis. (cellulase, Solvent + Gel) pectinase, ribulase..etc.) 5. Molecular6. Biodegradation. (bacteria, Interaction.(Ionic fungi, algae ..etc.) Interaction)
Model of Surface-to-volume Comparisons… Single Box Ratio 6 m2 2 3 1m 3 = 6 m /m Smaller Boxes Ratio 12 m2 3 = 12 m2/m3 1m Neglecting spaces between the smaller boxes, the volumes of the box on the left and the boxes on the right are the same but the surface area of the smaller boxes added together is much greater than the single box.
PROPERTIESStructural :- Platelets, Fibers, Spheroids, Linear, Branch, Network..etc.Physical & Chemical:- Like as Stiffness, Strength, Stability, etc. (2D,3D).Typical Structures are:• Linear (end-to-end, flexible) .• Branched(one end free, other attached to stalk polymer).• Network (similar to highly cross- linked structures,termosetting polymers).
Polymer has a MultidisciplinaryField of Science & Technology
Nano Based Polymers Types Chemical Synthetics - Polyglycolic acid (PGA) - Polylactic acid (PLA) - PGA-PLA - Polydioxanone (PDO) - Polycaprolactone - PGA-polycaprolactone - PLA-polycaprolactone - Polydioxanone-polycaprolactone Natural - Elastin - Gelatin collagen - Fibrillar collagen - Collagen blends - Fibrinogen - Heamoglobine
NANO BASED SOME POLYMERS ANDAPPLICATIONBroad Fields Nano Size Polymers Applications Chemicals PVC. (Poly vinyl chloride) Raincoats, shower curtains, water pipes PMMA. (Poly methyl Plastic base glasses methacrylate) PE. (Polyethylene) Grocery bags, shampoo, bottles, children’s toys, bulletproof vests PS. (Polystyrene) Comb, TVs body,. radio knobs. drinking cups foamy PP. (Polypropene) packaging, textiles (e.g. ropes, thermal underwear, carpets), stationery, plastic parts laboratory, equipment, loudspeakers, PPS. (Poly phenylene Resist chemical and thermal attacks sulfide) ABS. (Poly acrylonitrile Very strong and lightweight polymer. It is strong butadiene styrene) enough to be used to make automobile body parts PNBR. (Polymer Nitrile Cleaning of lab equipment, sophisticated, Buna-N rubber) instruments and examination gloves. Biological Immunogenic Immunoglobulin (IgA, IgD, IgE, IgG, IgM) Antigenic Epitope, Motifs, TCR (CD4,CD8), MHC Lipids Emulsions Mixture (HC+H2O) Liposomes Micelle, Amphipathic Metals Nanoshell Cover (Sphere) of NP Nanocomposites NP + Polymer Fibers Nanosphere Careers Nanoparticles(amino, carboxyl, surfaces) Nanocapsule Fiber Coat (Medicine coat, cover)
Outline Process of Nano-VectorNano polymer mostly can be very effective to be Designing aDrug as name “NANO VECTOR” by using of Nano Polymers andNano Materials in size nano range and also Applied for inducedtumor cells available in Critical Organs of Body such asBrain, Lung, Heart...etc. These vector designed a typicaltypes, who are search to target site, that target site a specificreceptor Presented in outer cell membrane of the tumor cellreceptor made be become Biomolecules it bind by various waysand released to NP into tumor cells. Where It are do The tumorCells Remove or Destroyed as may be possible without surgeryBecause Some Tumor Cell have arises to another Tumor Cell byCell Cycling, here break Cell Cycling by This Nano Vector will asa processing inhabit of protein synthesis of tumor cell.
Nano-Vector DNA Strand in nm
Nano-Vector DNA Strand Nanoparticle (Drugs)
Nano-Vector DNA Strand Covering of NP by DNA Polymer Nanoparticle (Drugs)
Nano-Vector DNA Strand Covering of NP by DNA Polymer Nanoparticle (Drugs)DNA Strand Covered of NP by DNA Polymer NP
vector with Moieties TargetDrug (Receptors)
Nanovector Moieties Targetwith Durg (Receptors)
vector with Moieties TargetDurg (Receptors)
vector with Moieties TargetDurg (Receptors) Nano vector with various moiety receptors
Assembled Nano Vector (Drug) Thank You for a kind Attention