Natalizumab to DMF switching
Published on: Mar 3, 2016
Transcripts - Natalizumab to DMF switching
Natalizumab DMF (Tecfidera)
Option 1: Immediate switch (no wash‐out)
Option 2: Three month overlap
M3 M4 M5 M6M0M‐1M‐2M‐3M‐4M‐5…… M‐6
3 month overlap
Hypothesis: A 3‐month overlap of DMF with natalizumab treatment will prevent rebound MRI
activity post‐natalizumab compared to no overlap of the treatments.
1° outcome: no. of Gd‐
enhancing lesions from M3‐M6
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