Haplo-identical bone marrow transplantation, “the glass is always half full” - 2014-10-09
A 25 year old IT professional was struck with Hodgkin ’s disease which is one of the most curable cancers. He was treated with standard chemotherapy and the disease went away only to reappear a few months later. This time he received local radiation and Autologous Bone Marrow Transplantation (BMT). However, the response was shortlived and the cancer sprung its ugly head within 6 months.
Published on: Mar 4, 2016
Transcripts - Haplo-identical bone marrow transplantation, “the glass is always half full” - 2014-10-09
Haplo-Identical Bone Marrow Transplantation,
?The Glass is Always Half Full?
Posted October 9th, 2014 by cancerhospitalindia
A New lease of Life for the patients of blood disorders,who need transplants but cannot find donors,
who are a perfect match to them.
New Delhi, Delhi, India., October 10, 2014 - (PressReleasePoint) -A 25 year old IT professional was
struck with Hodgkin ?s disease which is one of the most curable cancers. He was treated with standard
chemotherapy and the disease went away only to reappear a few months later. This time he received
local radiation and Autologous Bone Marrow Transplantation (BMT). However, the response was
shortlived and the cancer sprung its ugly head within 6 months.
The young man and his distraught family went from one centre to another. Various forms of
chemotherapy and a new drug called Brentuximab were suggested to him by the experts. However, the
drug Brentuximab had to be imported and each cycle of treatment would have costed 5 lakhs. Some
had suggested an Allogeneic BMT but his only brother was fully mismatched with him and this option
was no longer a consideration.
Dr Suparno Chakrabarti and Dr Sarita Jaiswal had been running a HAPLOIDENTICAL BMT
PROGRAM in the country for 3 years and the patient and his father came to them at Dharamshila
BMT Centre despite all the other experts in the country discouraging them to go for such an option. At
the outset, the patient was given standard chemotherapy which showed an initial response, but as it had
happened so many times before, the cancer bounced back. The patients parents were half matched with
him as expected, but the team at Dharamshila realised that just doing the BMT is not going to help the
young man. They identified a unique population of white blood cells in the father, but not in the mother
which could kill the tumour cells without causing any adverse reaction in the patient. They are called
?KIR ligand mismatched NK cells??. These cells were analysed and were found very effective in
killing tumour cells in the test tube. Dr Sarita Jaiswal had been trained in transplants involving such
cell manipulations at Italy and USA. The patient?s body could not have received any further intensive
chemotherapy. They sought help from Dr Kanika Sharma to administer a small dose of radiation to the
entire body keeping in mind that he has already received a very large dose of radiation to his heart,
lungs and neck. With this tiny dose of radiation and some immunosuppressive drugs the patient was
infused half matched cells from his father and 7 days later his father?s white cells were collected and
the special cells were separated and infused to the patient.
The stem cells from the father started growing in the patient after 2 weeks and he remained free of all
bacterial and viral infections since then. The blood and bone marrow of the patient were regularly
analysed and it showed that the cells from the father which were supposed to be killing the tumour
without causing any reaction in the patient, were growing in number.
Five months after the BMT, a PET scan was done to see the state of the cancer. To everyone?s joy and
surprise, it had disappeared completely.
Few such cases have been reported worldwide and this is the first time Indian doctors have used
innovation, science and technology to cure such a refractory cancer. Dr Sarita Jaiswal had seen some
very impressive results with Haploidentical BMT using cell manipulation, but to replicate the
procedure in its entirety would cost 40 lakhs at least. Hence, Dr Sarita innovated this unique way of
carrying out the Half matched BMT at a low cost and administer selective cells at the right time which
shall help in hitting the tumour as well as fighting infections.
Several such Haploidentical BMT using this unique and innovative technology are being carried out by
Dr Sarita Jaiswal at Dharamshila BMT Centre. Dr Sarita says that it is not just about giving the cells
but understanding the science behind it and applying it in the right context in the correct way. Dr
Suversha Khanna, who had long dreamt of a BMT unit at Dharamshila Hospital expressed her
satisfaction at the optimum utilisation of the world class infrastructure so painstakingly erected in the
hospital, 20 years after its inception. She said that that there is little point in having yet another BMT
centre, if it?s not going to make a difference to the majority of the suffering patients. Today, with the
infrastructure and the expertise of the BMT team, ably supported by Radiation Oncologists, its possible
that every patient who needs a BMT can have one from a Half matched (HAPLOIDENTICAL)
Parents, Siblings or Children and with the right choice of donor can even get cured of otherwise
refractory blood or lymph gland cancers. Dr Suparno Chakrabarti who had started such transplants for
the first time in India says that the ?glass is always half full?.
Dharamshila Hospital and Research Centre
Near New Ashok Nagar Metro Station,
Vasundhara Enclave, Delhi - 110096, INDIA
011 - 43066353
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Contact Suversha Khanna