Nanomedicine Dr Nedra Karunaratne
Nanotechnology and advanced material – Breakout
Published on: Mar 3, 2016
Transcripts - Nanomedicine Dr Nedra Karunaratne
Drug Delivery Mechanisms and Encapsulation
Prof. Nedra Karunaratne
heat, pH, moisture,
•Improved cell penetration
•Improved bioavailability/ solubility
•Reduced toxicity and side effects
•Low dose administration
•Protection from degradation
Production of polymeric colloidal particles with a therapeutic agent of
interest encapsulated within their polymeric matrix or adsorbed or
conjugated onto the surface.
Production of polymeric colloidal particles with a therapeutic agent
of interest encapsulated within their polymeric matrix or adsorbed
or conjugated onto the surface.
Carriers for encapsulation
• Natural polymers- chitosan, alginate,
• Synthetic polymers (biodegradable) –
• Lipids- phosphatadylcholine,
Ref: Int J Nanomedicine. 2014; 9: 4357–4373.
Sri Lankan Scenario
• Carbohydrate polymers- chitosan, alginate,
• Ref Chitosan coated liposomal delivery vehicle for prolonged release of amoxicillin.
M. A. S. K. Menikarachchi, K.A.N.P. Katuvawila, A. Ekanayake, V. Thevanesam, V. Karunaratne and D. N. Karunaratne
(Submitted to JNSF Nov 2014, revised Feb 2015, rerevised Apr 2015 and Sept
2015- still under review)
• Proteins and peptides- whey proteins,
albumin, small peptides
• Ref Use of chickpea protein for encapsulation of Folate to enhance nutritional
potency and stability. P.G.I.R. Ariyarathna and D.N. Karunaratne. Food and Bioproducts
Processing. (2015) 95 , 75 – 82
• Serum stability and Physicochemical Characterization of a Novel Amphipathic
peptide C6M1 for siRNA delivery. M. Jafari, W. Xu, R. Pan, C. M. Sweeting, D. N. Karunaratne, and P. Chen.
PLOS ONE (2014) 9(5): e97797
Sri Lankan Scenario
• Synthetic polymers -Not known
• Nanoparticles – eg. iron oxide nanoparticles
for drug delivery are being researched by two
groups in Colombo and Peradeniya.
Sri Lankan Scenario
• Lipids – liposomes, micelles, emulsions, solid-
• Ref. Enhanced Liposomal Encapsulation of Ascorbic Acid by the Liquid Crystal b-
sitosteryl-β-D-glucopyranoside. D. M. D. S. Dissanayake, D. N. Karunaratne, and A. D. L. C. Perera. Mol.
Cryst. Liq. Cryst, (2015) 613 (1) 94 - 102.
• Optimization of a Liposomal Delivery System for the Highly Antioxidant Methanol
Extract of Stem-bark of Schumacheria castaneifolia Vahl. K.M.G.K. Pamunuwa, C. J. Bandara, V.
Karunaratne and D. N. Karunaratne. J. Chem. Pharm. Res. (2015) 7 (4) 1236 - 1245.
• Improved skin permeability of dl-α-tocopherol in topical macroemulsions. D.N.
Karunaratne, A.C. Dassanayake, K.M.G.K. Pamunuwa and V. Karunaratne. Int. J. Pharm. Pharmaceutical
Sci. (2014) 6 (6) 53 -57.
Innovative Nanomedicine Developments in
• InnoMedica, a Swiss nanomedicine company led by Dr. Peter Halbherr, is working towards
developing a new nanocarrier platform to transport anti-cancer drugs directly to tumours,
thereby avoiding the toxic effect of the drug on healthy cells.
• The platform will deliver existing active agents, initially Doxorubicin, encapsulated in
liposomes. The use of Doxorubicin in liposomes is well established and now off
patent, being originally released as Doxil.
• InnoMedica’s innovative step is to attach glycans to the surface of the liposomes. Glycans are
polymers of carbohydrates, also known as polysaccharides. As an imitation of the detection
system of inflammation sites of the immune system, the patented glycan based targeting
quickly brings the drug to the cancer site - resulting in a better efficacy, lower dosage and
less side effects.
• * Technology for Chitosan coated liposomal delivery system already perfected in Peradeniya-
pending journal acceptance
• ** Doxorubicin encapsulated in chitosan nanoparticles, as well as doxorubicin in chitosan-
alginate nanoparticles already perfected. Submitted for publication.
This work was performed with HETC funding at Peradeniya.
• Invest in Paharmaceutical manufacturing
• Invest in research on nanodelivered drugs-
identify bona fide researchers
• Incentives for collaborations between
companies and Universitities
• Incubation cells in nanoscience parks.
• Animal models for testing drug efficacy is a
neccesity. (tumour models in animals)
• We can do it if the correct atmosphere is
• Thank you
Dendrimers are not encapsulates- but conjugates